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15) Effect of long-term treatment with paroxetine in patients major depressive disorder: A review of the literature Abstract: This review was done to look at the clinical effects of paroxetine compared with other antidepressants in patients depressed after at least 6 months of therapy with another depressive medication. Primary endpoint was change from baseline in depressive symptoms after paroxetine treatment compared with placebo.
Design: Prospective cohort.
Setting: A double blind, prospective randomized controlled trial.
Patients: Patients with major depressive disorder who met one or more of the following criteria: had a remission of at least 2 months using an antidepressant alone or concomitant with fluoxetine, compared to a minimum of 1 month with a fluoxetine-free period; had been experiencing major depressive disorder (≥15% score on the Hamilton depression rating scale during follow-up)
Interventions: Parenteral and oral paroxetine were administered in either 2 mg, 5 or 10 mg dosing increments.
Main Outcome Measures: Treatment defined as at least 1 week treatment with a 5 mg increase in dosing as well the use of any other prophylaxis/intervention and/or placebo.
Results: Overall, 704 men and 603 women underwent the study. A total of 8.7% cases were treated with paroxetine in one of the active doses and 1.3% in the other. Of 12 patients who received 5 mg for depression, 7 patients received 10 mg dosing, 4 patients took 10 mg, and 2 patients did not receive either dosing. For 16 patients who received at least wellbutrin uk prescription 7.5 mg dosing of paroxetine, 6 received 10 mg, 3 7.5 and 4 received Buy albuterol vials online 6.5 mg 1 5
Conclusion: A total of 8.7% patients experienced at least 1 month or more relief from depression following paroxetine treatment and in 6% of patients this occurred at the highest dose. Paroxetine was well tolerated in patients who were depressed on the entire course of treatment.
Paroxetine does not seem to cause major depressive disorder. It is effective in depressed patients on an as prescribed basis and it may provide long-term treatment benefit if used concomitantly with other antidepressant agents that are currently used medically in treatment of depression.
Although this review of drug's effects on the course of Major Depressive Disorder in comparison with.
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